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PUBLICATIONS
Dynaflow publications››
Cellaxess publications››
Cellectricon publications›› |
Scientific presentations at meetings ›› |
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DYNAFLOW®
RELATED PUBLICATIONS
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MEC-2 and MEC-6 in the Caenorhabditis
elegans Sensory Mechanotransduction Complex: Auxiliary Subunits that Enable
Channel Activity
Abstract››
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J. Gen. Physiol., Jun 2008;
131: 605 - 616.
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Austin L. Brown(1), Zhiwen Liao(2),
and Miriam B. Goodman(1,2)
1) Biophysics Program and 2) Department of Molecular and Cellular Physiology,
Stanford University, Stanford, CA 94305
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Differential Structure of Atrial
and Ventricular KATP Atrial KATP Channels Require SUR1
Abstract›› |
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Circulation Research. 2008
Published online before print October 30, 2008, doi: 10.1161/CIRCRESAHA.108.178186 |
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Thomas P. Flagg(1); Harley T.
Kurata(1); Ricard Masia(1); George Caputa(1); Mark A. Magnuson(2); David
J. Lefer(3); William A. Coetzee(4); and Colin G. Nichols(1)
1) Department of Cell Biology and Physiology, Washington University School
of Medicine, St Louis, Mo; Department of Molecular Physiology 2) Biophysics,
Vanderbilt University School of Medicine, Nashville, Tenn 3) Department
of Medicine and Pathology, Albert Einstein College of Medicine, New York;
4) Department of Pediatrics, New York University School of Medicine.
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Role of cAMP sensor Epac as
a determinant of K-ATP channel ATP-sensitivity in human pancreatic beta
cells and rat INS-1 cells
Abstract››
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Kang et al. J Physiol.2008;
0: jphysiol.2007.143818v1 |
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Guoxin Kang, Colin A Leech,
Oleg G Chepurny, William A Coetzee, and George G Holz
New York University School of Medicine |
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A Mircofluidic approach to
patch-clamp based ion channel safety testing
American
Biotechnology Laboratory››
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American Biotechnology Laboratory,
April 2008 |
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F. Pettersson, C. Johansson,
S. Braum, J. Sinclair.
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Gain-of-Function Mutations in
the MEC-4 DEG/ENaC Sensory Mechanotransduction Channel Alter Gating and
Drug Blockade
Abstract››
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J. Gen. Physiol., Jan 2007;
129: 161 - 173. |
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Austin L. Brown(1), Silvia M.
Fernandez-Illescas(2), Zhiwen Liao2, and Miriam B. Goodman(1,2)
1) Biophysics Program and 2) Department of Molecular and Cellular Physiology,
Stanford University School of Medicine, Stanford, CA 94305
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Controlling Desensitized States
in Ligand-Receptor Interaction Studies with Cyclic Scanning Patch-Clamp
Protocols
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Anal. Chem.; 2006; ASAP Article;
DOI: 10.1021/ac060812z |
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Daniel Granfeldt(1), Jon Sinclair(2),
Maria Millingen(1), Cecilia Farre(2), Per Lincoln(1) and Owe Orwar(1)
1) Department of Chemical and Biological Engineering, Physical Chemistry,
Chalmers University of Technology, SE-412 96 Göteborg, Sweden 2) Cellectricon
AB, Fabriksgatan 7, SE-412 50 Göteborg, Sweden
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A Biohybrid Dynamic Random Access
Memory
Abstract›› |
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J. Am. Chem. Soc.; 128(15),5109-5113
(doi:10.1021/ja0580993), (2006) |
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Jon Sinclair(1), Daniel Granfeldt(1),
Johan Pihl(2), Maria Millingen(1), Per Lincoln(1), Cecilia Farre(2), Lena
Peterson(3), and Owe Orwar(1)
1) Department of Chemistry and Bioscience and Microtechnology Centre, Chalmers
University of Technology, SE-412 96 Göteborg, Sweden 2) Cellectricon AB,
Fabriksgatan 7, SE-412 50 Göteborg, Sweden 3) Department of Signal and Systems,
Chalmers University of Technology, SE-412 96 Göteborg, Sweden
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An isoflurane- and alcohol-insensitive
mutant GABAA receptor 1 subunit with near normal apparent affinity for GABA:
characterization in heterologous systems and production of knock-in mice.
Abstract››
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J. Pharmacol. Exp. Ther. 2006:
jpet.106.104406v1 |
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Cecilia M. Borghese (1), David
F. Werner (2), Norbert Topf (3), Nicole V. Baron (3), L. Ashley Henderson
(4), Stephen L. Boehm II (5), Yuri A. Blednov (4), Abdallah Saad (6), Shuiping
Dai (6), Robert A. Pearce (6), R. Adron Harris (1), Gregg E. Homanics (2),
Neil L. Harrison (3)
1) University of Texas - Austin 2) University of Pittsburgh 3) Weill Medical
College of Cornell University 4) University of Texas at Austin 5) State
University of New York - Binghamton 6) University of Wisconsin - Madison
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Blocking Characteristics of
hERG, hNav1.5, and hKvLQT1/ hminK after Administration of the Novel Anti-Arrhythmic
Compound AZD7009
Abstract››
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J Cardiovasc Electrophysiol,
16(3), 329-341,(2005) |
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Frida Persson, M.Sc.,Leif Carlsson,
Ph.D., Göran Duker, Ph.D., and Ingemar Jacobson, Ph.D.
AstraZeneca R&D Mölndal, Mölndal, Sweden |
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Technology Feature:
Cell biology, Maximizing return.
Ion channels, stem cells and cell signalling are the focus of intense interest
in both cell biology and drug discovery. Pete Moore takes a look at what's
on offer for the researcher.
Abstract›› |
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Nature, Dec 1, 439 (6817),
p697-699 (2005). doi:10.1038/438699b |
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Pete Moore |
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Cellectricon Expands Flagship
Chip Tech to Compete in Growing hERG Screening Market.
Cell-Based
Assays News››
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Cell-Based Assays News, 12/5/2005 |
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Ben Butkus |
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Blocking characteristics
of hKv1.5 and hKv4.3/hKChIP2.2 after administration of the novel antiarrhythmic
compound AZD7009
Abstract››
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Journal of Cardiovascular
Pharmacology 46(1): 7-17. (2005). |
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Persson, Frida
MSc; Carlsson, Leif PhD; Duker, Goran PhD; Ingemar Jacobson PhD
AstraZeneca R&D Mölndal, Mölndal, Sweden |
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A Microfluidics
Approach to the Problem of Creating Separate Solution Environments Accessible
from Macroscopic Volumes
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Analytical Chemistry;
76(17), 4968 - 4976, (doi:10.1021/ac035527j), (2004) |
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Jessica Olofsson(1),Johan
Pihl(1),Jon Sinclair(3),Eskil Sahlin(2), Mattias Karlsson(2), and Owe
Orwar(1)
1)Department of Chemistry and Bioscience, and Microtechnology Centre, Chalmers
University of Technology, SE-412 96 Göteborg, Sweden, 2) Cellectricon AB,
Fabriksgatan 7 SE-412 50 Göteborg, Sweden, and 3) Department of Chemistry,
Gothenburg University, SE-412 96 Göteborg, Sweden
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Stabilization of
High-Resistance Seals in Patch-Clamp Recordings by Laminar Flow
Abstract››
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Analytical Chemistry;
75(23), 6718-6722, (2003), (Technical Note) |
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Jon Sinclair, Jessica
Olofsson, Johan Pihl, and Owe Orwar
Department of Physical Chemistry and Microtechnology Centre, Chalmers University
of Technology, SE-412 96 Göteborg, Sweden
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A Cell-Based Bar
Code Reader for High-Throughput Screening of Ion Channel-Ligand Interactions
Abstract››
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Analytical Chemistry;
Dec 15, 74(24), 6133-6138 (2002) |
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Jon Sinclair(1),Johan
Pihl(1), Jessica Olofsson(1), Mattias Karlsson(1), Kent Jardemark(3), Daniel
T. Chiu(2), and Owe Orwar(1)
1) Department of Physical Chemistry, and Microtechnology Centre, Chalmers
University of Technology, SE-412 96 Göteborg, Sweden 2) Department of Chemistry,
University of Washington, Seattle, Washington 98195-1700 3) Department of
Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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A chemical waveform
synthesizer
Abstract››
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PNAS; 102(23),
8097-8102, (doi:10.1073/pnas.0500230102), (2005) |
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Jessica Olofsson(1),
Helen Bridle(1), Jon Sinclair(1), Daniel Granfeldt(1), Eskil Sahlin(2),
and Owe Orwar(1)
1) Department of Chemistry and Bioscience and Microtechnology Centre, Chalmers
University of Technology, SE-412 96 Göteborg, Sweden 2) Department of Chemistry,
Göteborg University, SE-412 96 Göteborg, Sweden
Edited by Richard N. Zare, Stanford University, Stanford, CA
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Screening of ion
channel receptor agonists using capillary electrophoresis-patch clamp detection
with resensitized detector cells
Abstract››
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Anal. Chem., Mar
15, 73(6), 1228-33 (2001) |
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Cecilia Farre(1),
Andreas Sjöberg(1), Kent Jardemark(1), Ingemar Jacobson(2), and Owe
Orwar(1)
Department of Chemistry, Göteborg University, SE-412 96 Göteborg, Sweden,
and AstraZeneca AB, SE-431 83 Mölndal, Sweden
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Microfluidic Gradient
Generating Device for Pharmacological Profiling
Abstract››
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Analytical Chemistry;
77(13), 3897-3903, (doi:10.1021/ac050218+), (2005) |
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Johan Pihl(1),
Jon Sinclair(1), Eskil Sahlin(2), Mattias Karlsson(3), Fredrik Petterson(3),
Jessica Olofsson(1), and Owe Orwar(1)
1) Department of Chemistry and Bioscience, and Microtechnology Centre, Chalmers
University of Technology, SE-412 96 Göteborg, Sweden 2) Department of Chemistry,
Göteborg University, SE-412 96 Göteborg, Sweden 3) Cellectricon AB, Fabriksgatan
7 SE-412 50 Göteborg, Sweden
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Microfluidic technologies
in drug discovery
Abstract››
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Drug Discovery
Today, Vol 10, Number 20, October 2005 |
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Johan Pihl, Mattias
Karlsson, Daniel T. Chiu |
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Methods in channel
drug screening based on voltage- and patch-clamp recordings
DrugPlus
International ››
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Drug Plus International,
Nov-Dec 2003, Vol. 02, Number 4 |
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Cecilia Farre,
Mattias Karlsson |
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Cellectricon Sets
Sights on US Market for Microfluidics Tool
Cell-Based
Assays News›› |
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Cell-Based Assay
News (June 1), Published in Special quarterly digest with Cell-Based Assay
News’ most popular stories from the second quarter of 2004. |
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Ben Butkus |
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Microfluidics and
Patch-Clamp Based Sensors
Genetic
Engineering News››
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Genetic Engineering
News, Vol. 24, No 21, December 2004 |
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Cecilia farre,
Mattias Karlsson, Jon Sinclair |
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Ion Channel Drug
Targets – New automation Technologies Fuel Interest
Genetic
Engineering News››
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Genetic Engineering
News, Vol. 24, No.19 , November 2004 |
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Sue Pearson, Ph.
D. |
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Patch clamp electrophysiology
steps up a gear
European
Pharmaceutical News››
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European Pharmaceutical
review, Issue 2, 2005 |
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Derek J. Trezise,
Assay & Compound Profiling, GlaxoSmithKline Research & Development |
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Microfluidic Chip
Solutions for Increasing Throughput and Data Quality in Patch-Clamp Based
Drug Screening
American
Biotechnology Laboratory››
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American Biotechnology
Laboratory, July 2004, Vol. 22, No. 8 |
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Cecilia Farre,
Mattias Karlsson |
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The Patch Clamp
Goes Planar -
New configuration makes electrophysiology's classic tool easier, and ready
for high-throughput work
The
Scientist››
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The Scientist 19
(10):18 (23 May 2005) |
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Karen Heyman |
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Probing
Ion Channel Function
Cellectricon develops the next generation of patch-clamp technology
The
Scientist››
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The Scientist 17
(19):41 (6 October 2003) |
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Aileen Constans |
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Functional Cell-Based
High Throughput Drug Screening
Drug
Discovery World››
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Drug Discovery
World, Volume 5, Issue 2, Spring 2004 |
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Prof Daniel Chiu
and Prof Owe Orwar |
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Automated Electrophysiology:
High Throughput of Art
Abstract››
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ASSAY and Drug
Development Technologies. Oct 2003, Vol. 1, No. 5: 695-708 |
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Xiaobo Wang, Min
Li |
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Microfluidic
device for creating gradients
Abstract››
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Anal.
Chem. A-Pages ; 2005; 77(13); 245A-245A. |
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Rajendrani
Mukhopadhyay |
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CELLAXESS®
RELATED PUBLICATIONS
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An NGF-responsive element targets myo-inositol
monophosphatase-1 mRNA to sympathetic neuron axons
Abstract››
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Nature Neuroscience 2010, 13, 291 - 301 |
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Catia Andreassi, Carola Zimmermann, Richard
Mitter, Salvatore Fusco, Serena Devita, Adolfo Saiardi & Antonella Riccio |
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FUNCTIONAL DIFFERENCES BETWEEN D1 AND D5
REVEALED BY HIGH RESOLUTION IMAGING ON LIVE NEURONS
Abstract››
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Neuroscience 2009, 164, 463–469 |
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M. KRUUSMÄGI, S. KUMAR, S. ZELENIN,
H. BRISMAR, A. APERIA AND L. SCOTT*
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Generation of Focused Electric
Field Patterns at
Dielectric Surfaces
Abstract››
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Anal. Chem. 2005, 77, 4667-4672 |
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Jessica Olofsson(1), Mikael
Levin(2), Anette Strömberg(2), Stephen G. Weber(3), Frida Ryttsén(2), and
Owe Orwar(1)
1) Department of Chemistry and Bioscience, Chalmers University of Technology,
SE-412 96 Gothenburg, Sweden 2) Cellectricon AB, Fabriksgatan 7, SE-412
50 Gothenburg, Sweden 3) Department of Chemistry, University of Pittsburgh,
Pittsburgh, Pennsylvania 15260
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Electroporation
of Single Cells and Tissues with an Electrolyte-filled Capillary
Abstract››
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Anal. Chem., Sept
15, 73(18), 4469-4477 (2001) |
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K. Nolkrantz, C.
Farre, A. Brederlau, R.I.D. Karlsson, C. Brennan, P.S. Eriksson, S.G. Weber,
M. Sandberg, O. Orwar |
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Functional Screening of Intracellular
Proteins in Single Cells and in Patterned Cell Arrays Using Electroporation
Abstract››
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Anal. Chem. 2002, 74, 4300-4305 |
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Kerstin Nolkrantz, Cecilia Farre,
K. Johan Hurtig, Petra Rylander, Owe Orwar |
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Single-cell electroporation
Abstract›› |
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Current Opinion in Biotechnology;
14(1), 29-34 (2003) |
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Jessica Olofsson, Kerstin Nolkrantz,
Frida Ryttsén, Bradley A. Lambie, Stephen G. Weber, Owe Orwar |
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Electroporation and the Single
Cell, New technologies increase the resolution of electroporation
The Scientist››
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The Scientist 18 (8):46 (26
April 2004) |
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Aileen Constans |
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Fish Eggs Spawn a DNA Delivery
Revolution - Caviar inspires a Berkeley bioengineer to take electroporation
to the single-cell level
The Scientist››
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The Scientist 19 (13):34 (4
July 2005) |
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Laura lane |
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COMPANY RELATED
PUBLICATIONS
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Life Science Technologies
Microfluidics—Bringing New Things to Life Science
Abstract››
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AAAS/Science, 6 November 2008 |
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Jeffrey M. Perkel |
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Altering the Biochemical State
of Individual Cultured Cells and Organelles with Ultramicroelectrodes
Abstract››
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PNAS, 95, 10356-10360 (1998) |
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J. A. Lundqvist, F. Sahlin,
M. A. I. Åberg, A. Strömberg, P. S. Eriksson, O. Orwar |
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Characterization of single-cell
electroporation by using patch-clamp and fluorescence microscopy
Abstract››
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Biophys. J., Oct; 79(4): 1993-2001
(2000) |
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Ryttsen F, Farre C, Brennan
C, Weber SG, Nolkrantz K, Jardemark K, Chiu DT, Orwar O. |
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Selective introduction of
antisense oligonucleotides into single adult CNS progenitor cells using
electroporation demonstrates the requirement of STAT3 activation for CNTF-induced
gliogenesis
Abstract››
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Mol. Cell. Neurosci., Mar, 17(3),
426-43 (2001) |
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Åberg MA, Ryttsen F, Hellgren
G, Lindell K, Rosengren LE, MacLennan AJ, Carlsson B, Orwar O, Eriksson
PS. |
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Manipulating the Genetic Identity
and Biochemical Surface Properties of Individual Cells with Electric-Field-Induced
Fusion
Abstract››
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PNAS, 97(1), 7-11(2000) |
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A. Strömberg, F. Ryttsén,
D. T. Chiu, M. Davidson, P. S. Eriksson, C. F. Wilson, O. Orwar, R. N. Zare |
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Electroinjection of colloid
particles and biopolymers into single unilamellar liposomes and cells for
bioanalytical applicatons
Abstract››
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Anal. Chem., 72(23), 5857-5862
(2000) |
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M. Karlsson, K. Nolkrantz, M.
J. Davidson, A. Strömberg, F. Ryttsén, B. Åkerman, O.
Orwar |
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Chemical transformations in
individual ultrasmall biomimetic containers
Abstract›› |
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Science, 283, 1892-1895 (1999) |
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D. T. Chiu, C. F. Wilson, F.
Ryttsén, A. Strömberg, C. Farre, A. Karlsson, S. Nordholm, A.
Gaggar, B. P. Modi, A. Moscho, R. A. Garza-López, O. Orwar, R. N.
Zare |
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Cellectricon, in a field of
its own - Accelerating drug discovery processes
Zillion Business Review››
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Zillion, Fourth edition –
January 2005 |
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Cellectricon: Insights from
inside
BioCentury››
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BioCentury, Volume13, Number
7 |
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Ludger Wess |
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